ADM and cancer: A dual role of Ramp2 has been described in different cancer types; thus Ramp2 and its ligand adrenomedullin were shown to be overexpressed and to promote vascularization and metastasis in human colon cancer [30], while RAMP2 expression has been suppressed by promoter hypermethylation in lung cancer, and ectopic expression of RAMP2 directed apoptosis and inhibited lung cancer cell growth [31].