An oncogenic role of Jmjd8 as a positive regulator of TNF-induced NF-κB signaling in colorectal cancer has been described [34,35]; however, a recent study demonstrated that JMJD8 knockdown promotes cell proliferation and double-strand base (DSB) repair in lung and bone cancer cells, suggesting that Jmjd8 could represent a potential target for more effective tumor radio- and chemotherapies [36]. Here, TNF is linked to bone cancer.