TP53 and neoplasm: Compounds MI-43 (46), MI-63 (47), and MI-219 (48) showed excellent binding to the MDM2 protein (Ki~5.7 nM), and compound MI-219 (48) was recognized as a selective inhibitor of the p53–MDM2 interaction due to its ability to induce cell apoptosis in tumor cells without affecting healthy ones [39].