We observed an elevated level of ET-1 in 4T1 metastatic tumors as compared to that in 67NR tumor; moreover, the overexpression of RBP4 led to further elevation of its plasma level in mice bearing 67NR/RBP4 or 4T1/RBP4 tumors, indicating increasing endothelial dysfunction with increasing RBP4 expression in tumor cells. This evidence concerns the gene EDN1 and neoplasm.