Interestingly, a better correlation was observed when the PD-L1 expression was measured as combined positive score (CPS), defined as the number of PD-L1-positive cells (tumor cells, lymphocytes, and macrophages) divided by the total number of viable tumor cells and multiplied by 100 [43]; however, despite a higher ORR in patients with CPS >10, this result is comparable with single-agent chemotherapy [44]. This evidence concerns the gene CD274 and neoplasm.