MAPT and Alzheimer disease: In an effort to find potent GSK-3β inhibitors to target multifacets of AD [39], we report here a unique and potent GSK-3β inhibitor, 6-(5-(4-((pyridin-4-ylamino)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)quinolin-8-ol (B10), which has a direct effect on Aβ targets tau and metal dyshomeostasis, and promotes neuronal neurite outgrowth.