DHTKD1 and melanoma: To test for the specificity of OAds, Rots et al. compared the tumor-on/liver-off profiles of wildtype Ad5 and a replication competent Ad with E1A under the control of a melanoma-specific tyrosine promoter that restricts replication to malignant melanoma cells (AdTyrE1) in healthy human liver organotypic slices [64].