Moreover, we demonstrated that aminobisphosphonates such as zoledronic acid, a strong inhibitor of farnesyl pyrophosphate synthase (FPPS) [20], increase the intracellular accumulation and extracellular release of IPP in dendritic cells [17,19], activating Vγ9Vδ2 T-lymphocytes with anti-tumor activity. This evidence concerns the gene FDPS and neoplasm.