The presence of Notch ligands such as JAG1, DLL1, and DLL4 in malignant epithelial cells adjacent to the NOTCH2+ NOTCH3+ interface suggests a possible involvement of Notch signaling in the establishment of ameloblastoma invasiveness and in the interaction of malignant epithelial cells with the underlying stroma [18,53,66]. Here, NOTCH2 is linked to ameloblastoma.