MMP9 and malignant colon neoplasm: Since it is well known that the expression of MMP-9 is correlated with angiogenesis and metastasis of CRC [50], we hypothesized that NEM and CP could affect not only the MMP9 expression in colon cancer cells, but also the expression of EMT-related molecules such as e-cadherin, β-catenin and vimentin, all involved in the migration, invasion and angiogenesis of CRC cells.