This complex network includes both membrane-bound and soluble factors that contribute to the remodeling of the lymph node microenvironment towards a pro-leukemic immunotolerant milieu, where CLL cells receive stimulatory signals (e.g., aberrant activation of the BCR signaling) while directly orchestrating phenotypical and functional changes of immune response mediators. Here, BCR is linked to B-cell chronic lymphocytic leukemia.