Deregulation of the TIGIT/CD226/CD155 axis was described in several tumors: TIGIT+ tumor infiltrating CD8+ T cells could be detected in small-cell lung cancers, colorectal cancers and melanoma [93], and TIGIT inhibition was recently shown to increase T cell functions of melanoma specific CD8+ T cells [94]. The gene discussed is CD8A; the disease is colorectal cancer.