It is now clear that skewing of macrophage populations towards tolerance is primarily driven by CLL cells themselves, through the secretion of soluble factors [e.g., IL-10), adenosine, nicotinamide phosphorybosyltransferase (NAMPT)], as no M2 differentiation of CD14+ monocytes is achieved when cultured in vitro with normal B cells [11]. The gene discussed is IL10; the disease is B-cell chronic lymphocytic leukemia.