Functionally, TIGIT+/CD4+ T cells exhibit increased ability to sustain leukemic cell survival in co-culture experiments, and blocking TIGIT interactions using recombinant TIGIT-Fc molecules decreases CLL cells viability and interferes with production of prosurvival cytokines by CD4+ T cells [95]. The gene discussed is CD4; the disease is B-cell chronic lymphocytic leukemia.