To elucidate the molecular mechanism(s) responsible for melanoma cell death induction/execution under combined SOR/STV treatment, we evaluated the presence/expression of key apoptotic markers such as PARP cleavage and Mcl-1 degradation, in both cell lines treated 2, 4, or 6 h with SOR or STV alone or in combination by western blotting analysis. This evidence concerns the gene MCL1 and melanoma.