MiR-1246 is known to promote growth and metastasis of colorectal cancer cells and hepatocellular carcinoma by targeting CCNG2 or cell adhesion molecule 1, while miR-1246 inhibits cell invasion and epithelial-mesenchymal transition in prostate cancer and lung cancer cells by inhibiting N-cadherin and vimentin activities or targeting CXCR4 [23,24,25,26]. The gene discussed is CXCR4; the disease is colorectal cancer.