For example, the sesquiterpene guai-2-en-10α-ol, from Ulva fasciata, was reported to induce apoptosis and cell cycle arrest in G1 phase of triple-negative breast cancer (TNBC) cell line (MDA MB-231) via regulation of EGFR/PI3 K/Akt pathway [37] and laurinterol, from Laurencia okamurae, showed anticancer activity against melanoma cells (B16F1) through the p53-dependent pathway [65]. This evidence concerns the gene TP53 and melanoma.