MYCN and central nervous system cancer: This variability is consistent with studies reporting THZ1 effects on cell cycle arrest and apoptosis in T-ALL cells [9], G2 cell cycle block leading to DNA damage accumulation in high grade glioma [12], G2-M phase accumulation and apoptosis in MYCN-expressing neuroblastoma cells [10], and G2-M phase arrest in esophageal squamous cell carcinoma [28], as well as a study reporting no effects of THZ1 on cell cycle distribution in peripheral T-cell lymphoma [29].