In a recent study of 130 Han Chinese 46,XY males with hypospadias of variable degrees (associated or not with other DSD signs and/or other system involvement), 105 genes were analyzed on a panel including genes involved in gonadal/urogenital development (55 well recognized genes), CHH (seven genes), syndromic DSD (four genes), and others (39 genes) [14]. This evidence concerns the gene RMRP and disorder of sexual differentiation.