To analyze the effect of IFNGR1 deactivation in tumor cells on a pro-/anti-oncogenic role of immune cells, we depleted cluster of differentiation (CD)4+, CD8+, or natural killer (NK)1.1+ cells, or macrophages in mice bearing tumors with functional or deactivated IFNGR1 (Figure 2). This evidence concerns the gene IFNGR1 and neoplasm.