Actually, NLRP3 activity and metabolic disease progression have been associated with low levels of mitochondrial mitofusin proteins and elevated levels of DRP1, especially in hyperglycaemic conditions.108, 109 Yet, deletion of DRP1 may lead to an increase in NLRP3‐dependent caspase‐1 activation and IL‐1 secretion.110. Here, NLRP3 is linked to Other metabolic disease.