Recent evidence has shown that autophagy is necessary to reduce myocardial damage after acute myocardial infarction, thus confirming that the autophagic process can limit the activation of the NLRP3 inflammasome by removing damaged mitochondria and that impaired mitophagy may contribute to adverse cardiac remodelling in myocardial infarction.111, 112. This evidence concerns the gene NLRP3 and myocardial infarction.