Entries in the COSMIC database covering more than 7000 CTNNB1 mutations confirm that mutations at codons 33 and 37 are equally represented in human cancers and further show that the most mutated codons of CTNNB1 are 41 and 45 (https://cancer.sanger.ac.uk/cosmic/gene/analysis?ln=CTNNB1). This evidence concerns the gene CTNNB1 and cancer.