CTNNB1 and myotonic dystrophy type 1: In order to gain insight into the molecular mechanisms which might be responsible for the occurrence of multiple pilomatricomas and cancers in patients with DM1, we sequenced the CTNNB1 gene in five pilomatricomas and in one pilomatrical carcinoma from one patient with molecularly proven DM1 and further analyzed the tumors for microsatellite instability and for mutations in 161 cancer-associated genes.