While MPV17 silencing did not lead to depletion of mtDNA content in the tested cancer cell lines, in accordance with literature [9] [12], the resulting proliferation phenotypes associated with MPV17 shRNA-mediated knockdown were unsettling and inconclusive, leading us to perform a rescue experiment that eventually excluded a role of MPV17 in cancer cell proliferation. The gene discussed is MPV17; the disease is cancer.