Numerous genes associated with fatty acid metabolism were also down-regulated in CDAHFD-fed WT male mice compared to ND-fed counterparts, and these genes were further down-regulated in CDAHFD-fed Cyp2b-null male mice (Fig 8A and S2, S4, and S5 Files), suggesting greater steatosis in the CDAHFD-fed Cyp2b-null male mice. The gene discussed is CYP2B6; the disease is steatosis.