GPT and metabolic dysfunction-associated steatohepatitis: Common serum biomarkers of liver injury such as ALT, AST, and ALP increased in female mice fed a CDAHFD; however, CDAHFD-fed Cyp2b-null females exhibited significantly lower serum levels of these enzymes (28%, 42%, 29% lower respectively) compared to their WT counterparts, indicating Cyp2b-null female mice are protected from diet-induced NASH (Fig 3A).