As described in Section 3.6, the insulinLevel has a big impact on glycogen synthesis in the Liver. In order to compensate for lower insulin levels in the T2D subjects, the glucoseToGlycogenInLiver_ parameter in the simulations is assigned a much higher value for the T2D subject than for the normal subject (6.75 mg/kg/min versus 4.5 mg/kg/min). The gene discussed is INS; the disease is type 2 diabetes mellitus.