Nevertheless, among the PHF19L targets, we found several downregulated genes directly implicated in inhibition of tumor progression and metastasis in prostate cancer, such as IGFBP3 (Mehta et al., 2011) and NDRG2 (Gao et al., 2011; Figure 5E; Figure 5—figure supplement 1C left panel). This evidence concerns the gene IGFBP3 and Familial prostate cancer.