Indeed, by knocking down PHF19L, we observed significant induction of multiple genes known to promote changes in cytoskeleton and adhesion, extracellular matrix remodeling, invasion, and metastasis in prostate cancer (including SOX9, SOX4, MMP1, PLAU, EPCAM, CXCR4, LOX, and MET) (Darash-Yahana et al., 2004; Erler et al., 2006; Francis et al., 2018; Liu et al., 2017; Pulukuri and Rao, 2008; Banyard et al., 2014; Pennacchietti et al., 2003). This evidence concerns the gene PLAU and Familial prostate cancer.