We have examined HNF1A, a homeodomain transcriptional regulator of liver, gut, kidney, and pancreas, which has been proposed as a candidate pancreatic tumor suppressor (Molero et al, 2012; Stanger & Hebrok, 2013; Hoskins et al, 2014; Luo et al, 2015). This evidence concerns the gene HNF1A and pancreatic neoplasm.