To examine the relationship between Hnf1a and Kdm6a deficiency in pancreatic cancer, we generated mice with pancreas‐specific inactivating Kdm6a mutations and oncogenic Kras mutations [Pdx1Cre, Kdm6aLoxP/LoxP, KrasG12D, hereafter referred to as Kdm6apKO;KrasG12D mice (Appendix Fig S2A and B)]. Here, KRAS is linked to pancreatic neoplasm.