In a separate study, RUNX1 overexpression in a glioblastoma cell line down-regulated genes involved in the hypoxic response including the known HIF-1α targets hexokinase 2 (HK 2), caveolin 1 (CAV1), adenosine A2B receptor, and protein phosphatase 1 regulatory subunit 3C gene (PPP1R3C).99–101. The gene discussed is CAV1; the disease is glioblastoma.