Interestingly, cardiac up-regulation of RUNX1 does not appear to be specific to ischaemic pathology as RUNX1 was also found to be increased experimentally in animal models of: (i) diabetic cardiomyopathy; (ii) pressure overload; and (iii) dilated cardiomyopathy.51–53. Here, RUNX1 is linked to diabetic cardiomyopathy.