As shown previously (Aubart et al., 2014; Hostetler et al., 2019; Laar et al., 2012), aortic aneurysm and dissection are the main vascular findings, affecting, respectively 67% (104/155) and 29% (39/133) of all patients described with a SMAD3 variant (Table 1). Here, SMAD3 is linked to aortic aneurysm.