SMAD3 and osteoarthritis: The key role of SMAD3 and the TGFβ pathway in maintaining joint cartilage and preventing osteoarthritis has been reported several times (Chen, Thuillier, Chin, & Alliston, 2012), especially in mice model where a SMAD3 knock‐out model presents with similar articular damages than in human osteoarthritis (Yang et al., 2001).