The rat tail suspension model was further used to monitor melusin expression after exposure to muscle atrophy attenuators such as 7‐NI,3, 5 or curcumin, which upregulates Grp94/gp96,9 or MitoTEMPO, which inhibits mitochondrial‐derived oxidative stress and maintains sarcolemmal nNOS activity,7 as well as to evaluate the effects of exogenus melusin replacement, by means of in vivo transfection and viral infection. The gene discussed is HSP90B1; the disease is viral infectious disease.