Emerging evidence indicates that VEGF‐C can modulate the immune system to facilitate tumor cells to more easily escape immune surveillance.5, 6, 7, 21, 22 In addition, PD‐L1 can also promote tumor cells to escape from host immune attack.23, 24 To the best of our knowledge, the present research is the first study which exposes VEGFC and PD‐L1 expression in patients with lung adenocarcinoma and evaluates the relationship between their expression and prognosis of lung adenocarcinoma. The gene discussed is VEGFC; the disease is lung adenocarcinoma.