First, we found high VEGFC expression was significantly associated with poor survival in patients with lung adenocarcinoma, which is concordant with the results of other studies.25, 26 In our study, further analysis showed that in the gene mutations subgroup (patients with one of any three mutated genes) and stage I/II, stage III, acinar and nonacinar, there was a significant association between high expression of VEGFC and poor PFS. Here, VEGFC is linked to lung adenocarcinoma.