TLR2/MyD88 signaling induces PGE2 production by COX-2 transcription via NF-κB (49), during not only Mycoplasma infection (27, 50, 51) but also other bacterial infection such as Mycobacterium bovis (52), Mycobacterium leprae (53), and Staphylococcus aureus (54). The gene discussed is MYD88; the disease is Mycoplasmoides infection.