TLR2/MyD88 signaling induces PGE2 production by COX-2 transcription via NF-κB (49), during not only Mycoplasma infection (27, 50, 51) but also other bacterial infection such as Mycobacterium bovis (52), Mycobacterium leprae (53), and Staphylococcus aureus (54). This evidence concerns the gene PTGS2 and Mycoplasmoides infection.