Since IL-6 and CXCR4 are associated with proliferation, migration, and metastasis of CCA (47–49), upregulation of H19 and HULC may lead to aberrant expression of IL-6 and CXCR4 as well as poor survival rates of CCA patients although further studies are required (46). The gene discussed is CXCR4; the disease is cholangiocarcinoma.