In further support of this, regression analysis did not identify any role for possible baseline confounding factors related to patients' features, AOSD activity and concomitant treatments including the type of AOSD (systemic vs. chronic articular), baseline corticosteroid dosage, the concomitant use of cDMARDs, the systemic score and the severity of joint involvement assessed with the DAS28-CRP, the number of tender joints and the number of swollen joints. The gene discussed is CRP; the disease is adult-onset Still disease.