Thus by applying the unique mechanical unloading environment offered by both real and simulated-microgravity to bone (specifically, osteoporosis) research has led to the introduction of the FDA approved drug, Evenity, a monoclonal antibody that works as an anabolic agent to increase bone mass via the sclerostin pathway (Scheiber et al., 2019). This evidence concerns the gene SOST and osteoporosis.