Inversely, knockdown of FGFR4 reduces the migratory and invasive ability of CRC cells by upregulating epithelial marker E-cadherin and downregulating mesenchymal marker Snail, suggesting a pivotal role of FGFR4 in CRC metastasis (Peláez-García et al., 2013). Here, FGFR4 is linked to colorectal carcinoma.