For example, amplification of the FGF19 genomic locus including the well-established proto-oncogene CCND1, was found in liver cancer, breast cancer, lung cancer, bladder cancer and esophageal cancer (Sawey et al., 2011; Hoover et al., 2015; Tiong et al., 2016; Zhang et al., 2017). Here, FGF19 is linked to breast cancer.