RBP4 (Retinol-binding protein, 0.58-fold), is a well-known adipokine that serves as a signal from fat to other organs to control fuel usage in response to changes in adipose tissue mass and energy status (Yang et al., 2005), CAP1 (Adenylyl cyclase-associated protein 1, 0.44-fold) is a functional receptor for human resistin (Lee et al., 2014), a molecular link between inflammation, insulin resistance, obesity, and other cardiometabolic diseases (Lazar, 2007). This evidence concerns the gene RETN and obesity due to melanocortin 4 receptor deficiency.