Collectively, GSK-3α/β, ERK1, Akt1/2, JNK, RSK1/2, HSP27, p38, MSK2, p53, MKK3/6, and TOR when mutated or hyper-phosphorylated are implicated in biologically aggressive behaviors which could be used to develop an in vitro tumor model that could be used to explore drug discovery. The gene discussed is MAP2K3; the disease is neoplasm.