Collectively, GSK-3α/β, ERK1, Akt1/2, JNK, RSK1/2, HSP27, p38, MSK2, p53, MKK3/6, and TOR when mutated or hyper-phosphorylated are implicated in biologically aggressive behaviors which could be used to develop an in vitro tumor model that could be used to explore drug discovery. Here, MAPK8 is linked to neoplasm.