By identifying the miRNA–mRNA targeting relationship using the miRanda algorithm, it was shown that 18 miRNAs regulating the differential expression of PCGs were labeled as AD-related miRNAs by HMDD, and the targeted PCGs contained seven AD-related PCGs, including VTI1A, CUX1, S100B, AGT, CD44, IRAK4, and AQP1. This evidence concerns the gene AQP1 and Alzheimer disease.