Furthermore, correlations of HOMA-IR difference with sex hormone differences before and after intervention yielded no correlation for LH, FSH, DHEAS, and testosterone (r = −0.02, r = 0.11, r = 0.09, and r = 0.04; p > 0.05 for all; Figure S5), pointing to reduction in insulin resistance independent from pubertal state. This evidence concerns the gene BRD2 and Insulin resistance.