STAT3 and Sepsis: Our study identified immunomodulating molecules such as SERPINE1 (PAI-1), CCL2 (MCP-1), CXCL8 (IL-8), ICAM, IL-6, SOD-2, NFKB1A, STAT3, IL1RL1, and RPL (Figure 5A) responding to the microbial invasion consistent with previous studies investigating dysregulated systemic inflammatory responses in sepsis/septic shock (Khan et al., 2015; Hotchkiss et al., 2016).