CXCR4 and glioblastoma: In the main signaling pathways, Wnt/β-Catenin, TGFβ, PI3K/Akt, ERK, CXCR4, BIRC5, CTNNB1, FZD4, HGF, EGFR, and other proteins enhance the expression of EMT markers and promote the migration and proliferation of glioblastoma (13–17).