S100A4, cathepsin B, cyclin B1, Annexin A2, S100A10, TRIM21, 14-3-3 ζ/δ, and Ezrin may hence participate in tumor invasion depending on the grade of human CRCs, and protein upregulation during lymph node metastasis also suggests a positive correlation with metastasis in human CRCs. The gene discussed is ANXA2; the disease is neoplasm.