Results of flow cytometry and Hoechst 33258 staining studies showed that miR-661 promoted glioma cell apoptosis, while transfection of RAB3D partially rescued the apoptosis mediated by miR-661 mimics; furthermore, hsa_circ_0088732 further inhibited the glioma cell apoptosis mediated by miR-661 mimics and RAB3D (P < 0.05, P < 0.01, Figures 9A,B). Here, RAB3D is linked to central nervous system cancer.