In addition, the western blot results showed that knockdown of hsa_circ_0088732 downregulated N-cadherin and vimentin expression and upregulated E-cadherin expression, while overexpression of hsa_circ_0088732 induced N-cadherin and vimentin expression and reduced E-cadherin expression, suggesting that knockdown or overexpression of hsa_circ_0088732 inhibited or promoted glioma cell EMT, separately (Figures 3E,F). This evidence concerns the gene CDH2 and central nervous system cancer.