CD274 and cancer: Additionally, TMB assessed by WES [Figure 2B; AUC = 0.82 (Science-LUAD); and 0.80 (Cancer Cell-LUAD), respectively] also performed better than PD-L1 expression detected by IHC for predicting ICB response in LUAD [Figure S1A; AUC = 0.61 (Cancer Cell-LUAD); and 0.69 (JCO-LUAD), respectively].