Indeed, the E6 protein encoded by oncogenic HPVs has shown to down regulate both the tumor suppressors miR-34a, through the viral E6-mediated degradation of the oncosuppressor p53 (116, 117), and the miR-218, in a p53-independent manner thus causing over expression of its target laminin 5 β3 (LAMB3) gene in cervical SCC cells (63, 118). The gene discussed is TP53; the disease is neoplasm.