Recent advances in cancer genome sequencing allowed to identify further unknown mutations in MAPK1, HLA, EP300, FBXW7, NFE2L2, ERBB3, CASP8, TGFBR2, and SHKBP1 genes as well as sequence amplifications in CD274 (PD-L1), PDCD1LG2 (PD-L2), and BCAR4 (lncRNA BCAR4) genes (12, 13). This evidence concerns the gene CD274 and cancer.