PTGS2 and metastatic malignant neoplasm in the lymph nodes: Serum levels of cox2 and wnt3a also showed the prognostic potential in vessel invasion (cox2: AUC of 0.696, sensitivity of 73.9% and specificity of 63.2%, P = 0.011; wnt3a: AUC of 0.757, sensitivity of 78.3% and specificity of 63.2%, P = 0.001) and lymph node metastasis (cox2: AUC of 0.732, sensitivity of 80% and specificity of 62.7%, P = 0.021; wnt3a: AUC of 0.711, sensitivity of 70% and specificity of 76.5%, P = 0.036) and poor prognosis (cox2: AUC of 0.752, sensitivity of 80% and specificity of 73.2%, P = 0.002; wnt3a: AUC of 0.711, sensitivity of 75% and specificity of 58.5%, P = 0.008).