As a typical example, MicroRNA‐34a (miR34a) serves as a tumor suppressor in glioma, which is associated with tumor prognosis.19 Also, the level of sex‐determining region Y‐box 2 (SOX2), CD44, Notch, which is strongly related to the self‐renew and chemoresistance of GICs, was modulated by miR34a expression.20 Therefore, miR34a might serve as a powerful weapon against GICs, which would conquer the multiple signaling pathways associated with GICs stemness and drug resistance. The gene discussed is CD44; the disease is neoplasm.