To further determine the role of PINK1‐dependent mitophagy in myeloma pathogenesis in vivo, we crossbred pink1−/− mice with Eμ‐XBP‐1s transgenic mice (XBP‐1s+/+) and generated the XBP‐1s+/+/pink1−/− mice (Figure8A). This evidence concerns the gene PINK1 and plasma cell myeloma.