Although this study used HOMA2-IS and HOMA2-IR an estimate of insulin sensitivity and insulin resistance, respectively rather than the gold standard of hyperinsulinemic-euglycemic clamp, the HOMA2-IS and HOMA2-IR have been used in several cross-sectional studies and have been shown to be a reliable surrogate in determining measures of insulin resistance [54]. The gene discussed is INS; the disease is Insulin resistance.