While in AA without T2D only, serum 25(OH)D concentrations significantly explained the variances in TC (R2 = 0.168, B = − 0.329, P = 0.040), log leptin (R2 = 0.544, B = − 0.007, P = 0.021), and adiponectin (R2 = 0.144, B = 0.111, P = 0.033), but slightly associated with LDL-c (R2 = 0.133, B = − 0.278, P = 0.064), after adjustment for previously stated covariates. The gene discussed is LEP; the disease is type 2 diabetes mellitus.