NSD1 and Sotos syndrome: However, Berdasco and colleagues [12] studied the role of the NSD1 enzyme in neuroblastoma cancer and demonstrated that NDS1 disrupted can increase the malignancies in Sotos syndrome patients and its gene is involved in the control of the epigenetic silencing that leads the overexpression of the MEIS1 oncogene, showing the ability of NSD1 protein as a suppressor of tumour growth.