Concerning somatic mutations, CNA and expression of mRNA in the methyltransferases, NSD1, NSD2 and NSD3 together presented 115 genetic alterations of 615 CRC samples, almost 18% of alterations in colorectal samples, according to a TGCA provisional study obtained in CBioPortal repository for CRC (data obtained in CBioPortal <www.cbioprtal.org>, accessed in 28 June 2019). The gene discussed is NSD3; the disease is colorectal carcinoma.