The miRNA gene regulation network also revealed several CRC-related DERs, such as hsa-miR-1-3p, hsa-miR-133b, hsa-miR-133a-3p, hsa-miR-139-5p, hsa-miR-424-5p, hsa-miR-490-5p, and hsa-miR-542-5p, are associated with the regulation of CRC by targeting TIMP3, FOS, IGF1R, PPP1R12B, CCND2, and EGFR. The gene discussed is EGFR; the disease is colorectal carcinoma.