It had been found by Zhu Z J, et al. in osteosarcoma cells that hsa-miR-181a downregulated the expression of cleavage factor NUDT21 and therefore inhibited the proliferation and promoted the apoptosis of the cells, which were confirmed by miRNA knockdown and cell culture experiments (Zhu et al., 2016). This evidence concerns the gene NUDT21 and osteosarcoma.