Additionally, our data provided the first evidence of the interaction between miRNAs and APA associated with gene expression involved in CRC, suggesting that hsa-miR-133a-3p and MLEC, hsa-miR-145-5p and SET, hsa-miR-1-3p and PPIA, and hsa-miR-378d and YY1 might be novel and potential diagnostic biomarkers of CRC. Here, YY1 is linked to colorectal carcinoma.