We identified three genetic interactions, of which the best model was represented by BLK rs2736340T/C and BANK1 rs10516487G/A (testing accuracy 0.5443, and cross-validation consistency 10/10), this interaction also showed an association with susceptibility to RA (OR 1.65, p = 0.0001) (Table 4). This evidence concerns the gene BANK1 and rheumatoid arthritis.