Moreover, is has been documented a physical and genetic interaction between BLK and BANK1 (Castillejo-Lopez et al., 2012), which would support our finding of a BLK-BANK1 genetic interaction associated to RA (Castillejo-Lopez et al., 2012; Génin et al., 2013; Huang et al., 2017). This evidence concerns the gene BANK1 and rheumatoid arthritis.