The second best interaction model was formed by the BLK rs2736340T/C-rs13277113A/G plus BANK1 rs10516487G/A-rs3733197G/A genotypes (testing accuracy; 0.5381, and cross-validation consistency; 10/10), this interaction was also associated with RA (OR 1.79, p < 0.0001). The gene discussed is BLK; the disease is rheumatoid arthritis.