Although different BLK and BANK1 SNVs have been examined in patients with RA, the results are uncertain because some reports show an association with this AD (Gregersen et al., 2009; Orozco et al., 2009; Deshmukh et al., 2011; Freudenberg et al., 2011; Orozco et al., 2011; Viatte et al., 2012; Huang et al., 2017), while others have not replicated this finding (Suarez-Gestal et al., 2009; Génin et al., 2013; Jiang et al., 2014; Orozco et al., 2014; Bossini-Castillo et al., 2015; Julià et al., 2016; Zhu et al., 2016; Saxena et al., 2017). This evidence concerns the gene BLK and rheumatoid arthritis.