PROCR and malaria: Two studies (Naka et al., 2014; Shabani et al., 2017) that revealed EPCR rs867186-GG genotype could mediate protection against severe malaria only involved adult malaria patients, while the other three studies showed GPCR gene variants were not associated with severe malaria (Schuldt et al., 2014; Hansson et al., 2015) or increased mortality with cerebral malaria involved child malaria patients (Moussiliou et al., 2015).