PROCR and malaria: By competing with activated protein C (APC), PfEMP1-CIDRα1 binding to EPCR induces pro-apoptosis, pro-inflammation, coagulation, compromises cytoprotection and barrier functions of EPCR (Bernabeu and Smith, 2017; Lennartz et al., 2017; Pendurthi and Rao, 2018), and leads to severe malaria including CM and severe malarial anemia (SMA) (Mosnier and Lavstsen, 2016).