CMC2 and cerebral malaria: PfEMP1 containing DC13-variants are capable of binding to both the EPCR (Cham et al., 2009; Lavstsen et al., 2012; Turner et al., 2015; Bernabeu et al., 2016; Jespersen et al., 2016) and ICAM-1 (Howell et al., 2008; Joergensen et al., 2010; Bengtsson et al., 2013; Lennartz et al., 2017), where both are implicated in cerebral malaria.