PROCR and infection: For instance, ICAM-1-binding and rosetting via PfEMP1 are the virulence factors for severe malaria (Rowe et al., 2009), while EPCR-binding PfEMP1 dominates host infections with limited malaria immunity (Cham et al., 2009; Lavstsen et al., 2012; Turner et al., 2015; Bernabeu et al., 2016; Jespersen et al., 2016).