Two studies involving African and Thai adult malaria patients revealed that EPCR rs867186-GG genotype is associated with protection against severe malaria (Naka et al., 2014; Shabani et al., 2016), while three other studies (Schuldt et al., 2014; Hansson et al., 2015; Moussiliou et al., 2015) involving African child malaria patients showed that EPCR gene GG variants are not associated with severe malaria or increased mortality among children with CM. This evidence concerns the gene PROCR and malaria.